Name | vitamin E succinate |
Synonyms | vitamin E succinate Tocopherol succinate alpha-tocopherol,succinate D-alpha-Tocopherol Succinate alpha-tocopherolhemisuccinate DL-alpha-Tocopherol succinate D-a-Tocopherol acid Succinate (+)-α-TOCOPHEROL ACID SUCCINATE D-α-Tocopheryl succinate, Ph. Eur. alpha-tocopheryl hydrogen succinate (+)-A-tocopherol acid succinate from*natural A-to [2theta-[2theta(4theta,8theta)]]-cyl)-2h-1-benzopyran-6-yl]este butanedioicacid,mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltride butanedioicacid,mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltride 1210IU D-α-Tocopherol succinate,vitamin E succinate 1185IU D-α-Tocopherol succinate,vitamin E succinate |
CAS | 4345-03-3 |
EINECS | 224-403-8 |
InChI | InChI=1/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1 |
Molecular Formula | C33H54O5 |
Molar Mass | 530.78 |
Density | 1.002±0.06 g/cm3(Predicted) |
Melting Point | ~76°C(lit.) |
Boling Point | 625.8±55.0 °C(Predicted) |
Solubility | Insoluble in water. Soluble in chloroform. Soluble in acetone, ethanol, ether and vegetable oil. |
Vapor Presure | 0Pa at 20℃ |
Appearance | Colorless to white crystalline powder |
Color | White or off-white |
Maximum wavelength(λmax) | ['286nm(EtOH)(lit.)'] |
Merck | 14,9495 |
BRN | 4038233 |
pKa | 4.35±0.17(Predicted) |
Storage Condition | -20°C |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
Sensitive | Sensitive to heat |
MDL | MFCD00072055 |
WGK Germany | 1 |
RTECS | EJ9984000 |
FLUKA BRAND F CODES | 8-10-23 |
HS Code | 2936280000 |
Toxicity | LD50 oral in rat: > 7gm/kg |
Reference Show more | 1. [IF=4.213] Zhonghui Xie et al."Rapamycin loaded TPGS-Lecithins-Zein nanoparticles based on core-shell structure for oral drug administration."Int J Pharmaceut. 2019 Sep;568:118529 |
LogP | 12 at 25℃ |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
introduction | vitamin e succinate (VitaminESuccinate,VES) is a derivative of vitamin e. some studies have shown that VES can block the tumor cell cycle in G1 phase and promote tumor cell differentiation, inhibit tumor cell DNA synthesis, increase the secretion and activation of metastatic growth factor β(TGF-β) and enhance the expression of TGF-βII receptor, it can also induce tumor cell apoptosis. Natural vitamin esuccinate has been widely used in developed countries such as Europe, America and Japan. Almost all tablets and capsules The vitamin e used in nutritional supplements are vitamin esuccinate and calcium succinate, and vitamin esuccinate has a very obvious inhibitory effect on the growth of human cultured tumor cells. |
efficacy and function | 1. promote the absorption of VA and fat, improve the nutrient supply of the body, enhance the absorption and utilization of nutrients by muscle cells and other biological characteristics. 2. It can effectively delay aging. At the same time, due to its promotion of nucleic acid metabolism, it can effectively eliminate oxygen free radicals in the body, maintain the vigorous functions of various organs, and play a role in delaying aging and prolonging life. 3. It has preventive and therapeutic effects on muscle atrophy, cardiovascular and cerebrovascular diseases, infertility and abortion caused by VE deficiency. 4. Natural VE has a very good effect on menopausal disorders, autonomic disorders and high cholesterol, and can prevent anemia and effectively defend life. 5. in VE health care drugs, natural vitamin E succinate (d-alpha tocopheryl acid succinate) not only has the physiological activity function of natural vitamin E, but also has the same high stability as natural vitamin E acetate, and has unique anti-cancer health care function and immune regulation function. at present, it has become the most common raw material for VE drugs and health food drugs to prevent and treat tumors in the world. |
use | used for pressing multidimensional tablets, filling of hard capsules, additives for advanced health foods, and raw materials for advanced cosmetics. |
anti-cancer potential | has been proved in foreign experimental studies, the tumor cells in which vitamin E succinate VES exerts anti-proliferative effects include murine and human neuroblastoma, rat glioma, murine B- 16 melanoma, human prostate cancer, avian lymphoblastoma, human promyelocytic leukemia, human breast cancer, human B lymphoblastoma, murine EL4T lymphoblastoma and other malignant cells. The inhibition of VES on tumor growth has also been confirmed in the overall test. In the animal model of mouse cheek epithelial cancer, local injection of VES(4 weeks) can cause tumor regression. What is more exciting is that VES has no toxicity to normal cells and no growth inhibition, which further indicates the application prospect of VES. |
refined and purified | vitamin e succinate (VES) is more stable than vitamin e (VE), and has been widely used in medicine, cosmetics and other fields. The reaction solution of vitamin E succinate was obtained by using vitamin E and succinic anhydride as raw materials, acetone as solvent and triethylamine as catalyst. The reaction solution was cooled and left to stand for about 10 hours at 3 ℃, succinic anhydride was precipitated and precipitated, and the recovery rate was 82.6%:0.08MPa to distill triethylamine and acetone under reduced pressure. The residual distillate was dissolved with hexane, the solution was quickly precipitated and stratified, filtered and washed to obtain VES with a recovery rate of 82% and a purity of 93%. |